CASE Ultra Models

CASE Ultra models cover a wide variety of toxicity endpoints and are the largest collection of high quality in-silico toxicity models

Statistical Models & Expert Rules

Licensing Options

Bacterial Mutagenicity Models

CASE Ultra Bacterial Mutagenicity models are based on the experimental data from Ames test. The models cover both expert-rule and statistical methodologies for complete ICH M7 compliance

ICH M7 Models

Expert Rule-based model  for Bacterial Mutagenicity
Statistical models  for Bacterial Mutagenicity

Supporting Models

Additional Bacterial Mutagenicity models are available for supporting evidence which are related to strain and site specific mutagens, both with and without S9

Genotoxicity Models

The Genotoxicity endpoint includes Mutagenicity as well as other genotoxicity-relevant  in vitro and in vivo phenotypes, such as micronucleus, chromosomal aberrations, sister chromatid exchange and more. Models denoted as RCA are based on FDA data as part of Research Cooperation Agreement (RCA).

RCA Genotoxicity Models

Clastogenicity in vitro chromosome abberations, CHO and CHL cells
Clastogenicity micronucleus in vivo, mouse
Mouse Lymphoma, both activated and unactivated

Carcinogenicity Models

Cancer-related endpoints in human and rodents.
Models denoted as RCA are based on FDA data as part of Research Cooperation Agreement (RCA).

RCA Rodent Carcinogenicity (ICH M7 compatible)

Rodent carcinogenicity, both male and female rats & mice

Hepato Toxicity Models

Hepatobiliary adverse effects and general liver toxicity in human.
Models denoted as RCA are based on FDA data as part of Research Cooperation Agreement.

RCA HepatoToxicity Models

RCA human acute liver damage
RCA human liver tests (liver enzymes release)
RCA human bile duct disorders
RCA human cholestasis
Human gall bladder disorders

Renal Toxicity Models

Kidney and urinary tract adverse effects in human.
These models are based on FDA data as part of Research Cooperation Agreement (RCA).

RCA human renal disorders
RCA human nephropathy
RCA human kidney function tests
RCA human blood in urine disorders
RCA human urolithiasis
RCA human bladder disorders

Cardio Toxicity

Adverse effects of the heart and cardiovascular system disorders in human. These models are based on FDA data as part of Research Cooperation Agreement (RCA).

RCA human cardiac conduction disorders
RCA human coronary artery disorders
RCA human electrocardiogram disorders
RCA human cardiac failure
RCA human myocardial disorders
RCA human cardiac rate rhythm disorders
RCA human cardiac palpitations
RCA human cardiac arrhythmia disorders
RCA human cardiac QT-prolongation
RCA human tachycardia
RCA human bradycardia
RCA human myocardial infarction
RCA human cardiac Torsades de pointes

SkinEye Toxicity

Irritation and sensitization potential upon contact with skin or eye. These models can help in managing environmental impact and in cosmetics research.

Eye irritation (mouse, rabbit)
Skin Sensitization (LLNA, Buehler and GPMT)
Skin Irritation (Draize)
Carcinogenicity by skin application
Skin Corrosion

Mammalian Developmental and Reproductive Toxicity

Reproductive sytem disorders and adverse effects. These models are based on FDA data as part of Research Cooperation Agreement (RCA).

Fertility in males, mouse and rat
Sperm toxicity, mouse and rat
Fertility in females, rat and mouse
Newborn behavioral toxicity, rat and mouse
Fetal Dysmorphogenesis, rat, mouse, and rabbit

Supporting Models

Additional Reproductive and Developmental models are available for supporting evidence which are related to teratogenicity in rabbits, rats, mice, and mammals; developmental toxicity affecting fetal survival; anomalies in fetal development, and developmental toxicity affecting fetal survival.

Acute Toxicity Models

Acute toxicity endpoints. Models denoted as RCA are based on FDA data as part of Research Cooperation Agreement (RCA).

Rat acute toxicity, LD50, from NTP, WHO, RTECS and other data sources
Maximum tolerated dose, rat and mouse, NTP data source
RCA maximum tolerated dose > 500mg/kg, rat and mouse, by gender
RCA maximum tolerated dose < 50mg/kg, rat and mouse, by gender

EcoToxicity Models

Endpoints related to ecotoxicity and environmental hazard.

Bioconcentration factor for Red Killifish (CITI)
Bioconcentration factor for Common Carp CITI)
Biodegradability in sludge
Biodegradability (biological oxygen demand after 5 days)
Ready biodegradation (MITI)
Toxicity to environmental bacteria (MICROTOX EPA)
Toxicity to photobacteria, 15min
Toxicity to fish, including Blue Gill, Guppy, Minnow, Rainbow Trout, Red Killfish, and in-vitro Goldfish cells

Acute Inhalation Toxicity

Acute Inhalation Toxicity followed by OECD Guideline 403. This method provides information on health hazards likely to arise from short-term exposure to a test article (gas, vapor or aerosol/particulate test article) by inhalation.

Inhalation Toxicity for GHS Categories 1 through 4
Inhalation Toxicity, Acute, Rat 4 hours LC50

Endocrine Receptor Models

These models should be useful in the risk assessment of endocrine disrupting potential of chemicals where animal testing is not possible.

Androgen Agonist and Antagonists
Estrogen Agonists, Antagonist, and Binders
Aryl Hydrocarbon Receptor Activators