Genetic toxicity

Genetic Toxicity

	Mutagenicity
	Clastogenicity
	DNA Damage
	Genetic Toxicity

Mutagenicity

Module ID	Description	# of Compounds
A2H	Salmonella Ames Mutagenicity updated from NTP, GENETOX, FDA and others	5864
A99	Salmonella Mutagenicity of Pesticides	55
A9L	Salmonella mutation GeneTox 2003 (SAL+/- S9)	706
A9M	Salmonella mutation NTP 2003 (SAL+/- S9)	1549
A2N	Salmonella typhimurium (TA97) mutation in absence of S9	1007
A2O	Salmonella typhimurium (TA98) mutation in absence of S9	3456
A2P	Salmonella typhimurium (TA100) mutation in absence of S9	3781
A9A	Salmonella typhimurium (TA102) mutation in absence of S9	522
A9B	Salmonella typhimurium (TA104) mutation in absence of S9	276
A2L	Salmonella typhimurium (TA1535) mutation in absence of S9	2051
A2M	Salmonella typhimurium (TA1537) mutation in absence of S9	1558
A9C	Salmonella typhimurium (TA1538) mutation in absence of S9	646
A2T	Salmonella typhimurium (TA97) mutation in presence of Hamster S9	639
A2U	Salmonella typhimurium (TA98) mutation in presence of Hamster S9	1673
A2P	Salmonella typhimurium (TA100) mutation in presence of Hamster S9	1662
A9D	Salmonella typhimurium (TA102) mutation in presence of Hamster S9	39
A9E	Salmonella typhimurium (TA104) mutation in presence of Hamster S9	33
A2R	Salmonella typhimurium (TA1535) mutation in presence of Hamster S9	1476
A2S	Salmonella typhimurium (TA1537) mutation in presence of Hamster S9	948
A9F	Salmonella typhimurium (TA1538) mutation in presence of Hamster S9	218
A2Y	Salmonella typhimurium (TA97) mutation in presence of Rat S9	766
A2Z	Salmonella typhimurium (TA98) mutation in presence of Rat S9	2983
A2V	Salmonella typhimurium (TA100) mutation in presence of Rat S9	3214
A9G	Salmonella typhimurium (TA102) mutation in presence of Rat S9	424
A9H	Salmonella typhimurium (TA104) mutation in presence of Rat S9	216
A2W	Salmonella typhimurium (TA1535) mutation in presence of Rat S9	1757
A2X	Salmonella typhimurium (TA1537) mutation in presence of Rat S9	1469
A9I	Salmonella typhimurium (TA1538) mutation in presence of Rat S9	714
A2D	Drosophila Mutation	783
A6E	E.Coli mutation (CCRIS)	862
A6J	Mouse lymphoma L5178Y (TK+/TK-) +/-S9 (NTP, GENETOX, CCRIS)	910
A6O	SOS Chromotest	462
A7A	FDA Mutagenicity Microbial composite (Sal_Ecoli_Bac)	3682
A7B	FDA Mutagenicity Salmonella t. 5-strains	3573
A7C	FDA Mutagenicity E.coli composite	526
A7D	FDA Mutagenicity E.coli WP strains	279
A7E	FDA Mutagenicity Yeast composite	603
A7F	FDA Mutagenicity Yeast Sacharomyces	472
A7G	FDA Mutagenicity Drosophila composite	591
A7H	FDA Mutagenicity Drosophila sex linked rec	584
A7I	FDA Mutagenicity Drosophila heritable translocation	115
A7J	FDA Mutagenicity Mammal in vivo composite	214
A7K	FDA Mutagenicity Mammal in vivo dominant lethal	182
A7O	FDA Mutagenicity Mammal in vitro CHO V79 hgprt loci	641
A7N	FDA genetic toxicity gene mutation In vitro mouse lymphoma L5178y Control (research only)	810*
AN7	FDA genetic toxicity gene mutation in vitro mouse lymphoma L5178Y A (research only)	566*
AN8	FDA genetic toxicity gene mutation in vitro mouse lymphoma L5178Y B (research only)	565*

Salmonella TA97,TA98, TA100, TA102, TA104, TA1535, TA1537 and TA1538 strains modules are developed with four different flavors: experimental call, maximum fold, maximum effective concentration and rev/nmol.

* indicates modules updated or acquired in 2008.

Clastogenicity

Module ID	Description	# of Compounds
A60	NTP Sister Chromatid Exchange	585
A61	NTP Chromosomal Aberration	805
A62	Micronuclei Induction	904
A6A	Aneuploidy in Yeast	93
A6N	Sister Chromatid Exchanges - In Vivo	176
A7P	FDA Clastogenicity Chromosome abs in vivo composite	284
A7R	FDA Clastogenicity Chromosome abs in vivo Mouse	152
A7S	FDA Clastogenicity Micronucleus in vivo composite	820
A7T	FDA Clastogenicity Micronucleus in vivo mouse	622
A7U	FDA Clastogenicity in vitro chromosome aberrations composite control (research only)	1394*
A7V	FDA Clastogenicity in vitro chromosome aberrations CHO control (research only)	688*
A7W	FDA Clastogenicity in vitro chromosome aberrations CHL control (research only)	750*
A7X	FDA Clastogenicity in vitro human lymphocytes	187*
A7Y	FDA Clastogenicity in vitro SCE composite control	779*
AY7	FDA Clastogenicity in vitro SCE composite part A	412*
AY8	FDA Clastogenicity in vitro SCE composite part B	411*
AY9	FDA Clastogenicity in vitro SCE composite part C	411*
A7Z	FDA Clastogenicity in vitro SCE CHO	626*
A8I	FDA Clastogenicity in vitro SCE other cell types	204*
A8J	FDA Clastogenicity Micronucleus in vivo undef. species	441

* indicates modules updated or acquired in 2008.

DNA Damage

Module ID	Description	# of Compounds
A64	UDS Induction	299
A8A	FDA DNA Effects UDS composite	376
A8B	FDA Mutagenicity UDS rat hepatocytes	142
A8C	FDA Mutagenicity UDS human fibroblasts	197
A8K	FDA Mutagenicity UDS other cell	102

Genetic Toxicity

Module ID	Description	# of Compounds
A2E	Structural Alerts - Ashby	784
A6F	GENETOX (full database)	808

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Genetic Toxicity

Mutagenicity

Clastogenicity

DNA Damage

Genetic Toxicity

Send mail to saiakhov@multicase.com with questions or comments about this web site. Copyright © 2008 Multicase Inc Last modified: 08/06/08

Send mail to saiakhov@multicase.com with questions or comments about this web site.
Copyright © 2008 Multicase Inc
Last modified: 08/06/08