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  Carcinogenicity

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In Vivo Carcinogenicity

Module ID  Description # of Compounds
A06 All data from misc Carcin. databases 208
A0E CPDB Mouse Carcinogenicity 633
A0D CPDB Rat Carcinogenicity 742
A0C CPDB Rodent Carcinogenicity 430
A0L Mouse Two Stage Skin Carcinogenicity 206
A01 N-Nitroso compounds- 5% Daily Intake in Rats 64
A0H NTP Female Mouse Carcinogenicity 286
A0F NTP Female Rat Carcinogenicity 287
A0I NTP Male Mouse Carcinogenicity 286
A0G NTP Male Rat Carcinogenicity 314
A08 NTP Mouse Carcinogenicity 319
A09 NTP Rat Carcinogenicity 316
A07 NTP Rodent Carcinogenicity 313
A0J Human carcinogenicity IARC 628
AX1 Hepatocarcinogenicity MALE RAT 474
AX2 hepatocarcinogenicity FEMALE RAT 441
AX3 hepatocarcinogenicity MALE MOUSE 434
AX4 hepatocarcinogenicity FEMALE MOUSE 429
AF1 FDA Rodent Carcinogenicity Male Rat (non-proprietary) 1245*
AF2 FDA Rodent Carcinogenicity Female Rat (non-proprietary) 1239*
AF3 FDA Rodent Carcinogenicity Male Mouse (non-proprietary) 1127*
AF4 FDA Rodent Carcinogenicity Female Mouse (non-proprietary) 1137*
AFU FDA Male/Female rat and mouse (non-proprietary)(research only) 1445*
AFV FDA Male/Female rat (non-proprietary) 1298*
AFW FDA Male/Female mouse (non-proprietary) 1151*
AG1 FDA Rodent Carcinogenicity Male Rat (+proprietary) 1381*
AG2 FDA Rodent Carcinogenicity Female Rat (+proprietary) 1376*
AG3 FDA Rodent Carcinogenicity Male Mouse (+proprietary) 1252*
AG4 FDA Rodent Carcinogenicity Female Mouse (+proprietary) 1263*
AGU FDA Male/Female rat and mouse (+proprietary)(research only) 1589*
AGV FDA Male/Female rat (+proprietary) 1435*
AGW FDA Male/Female mouse (+proprietary) 1277*

* indicates modules updated or acquired in 2008.

"Research only"  modules are used by FDA ICSAS scientists for internal research and not for regulatory purposes. 

 

In vitro Carcinogenicity

Module ID  Description # of Compounds
A0K Inducing Glutathione S. Transferase positive preneoplastic lesions inrat livers 100
A0S Cell Transformation - Balb/C 3T3 183
A0T TCDD+PAH Binding to Aryl Hydrocarbon Hydroxylase receptor 148
A6C Inhibition of Metabolic Cooperation for cultured cells 251

A8D

FDA cell transformation composite (research only)

642*

A8E

FDA cell transformation SHE cells (research only)

427*

A8F

FDA cell transformation BALB/c 3T3 cells (research only)

317*

A8G

FDA cell transformation C3H10T1/2 cells (research only)

139*

 

* indicates modules updated or acquired in 2008.

"Research only"  modules are used by FDA ICSAS scientists for internal research and not for regulatory purposes. 

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Last modified: 08/06/08