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Teratogenicity

                                     

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  Teratogenicity

bulletDevelopmental toxicity
bulletDysmorphogenesis NEW!!!
bulletReproductive toxicity in male rodents
bulletReproductive toxicity in female rodents
bulletNeurotoxicity
bulletFetal development NEW!!!
bulletFetal survival NEW!!!

 

Developmental toxicity

 Module ID  Description # of Compounds
A41 Retinoids 39 compounds data from C.Willhite 39
A42 Retinoids 37 compounds data from Kochhar 37
A43 Developmental Toxicity Triazoles antifungal triazole alcohols 66
A44 Developmental Toxicity Composite 275
A45 Developmental Toxicants in Mouse 101
A46 Developmental Toxicants in Rat  134
A47 Developmental Toxicants in Rabbit 66
A48 Developmental Toxicants in Human 119
A49 FDA TERIS Developmental Toxicity in Humans 323
A4A Risk of Developmental Toxicity 323
A4B Developmental Toxicants in Hamster 192

 

Dysmorphogenesis

 Module ID  Description # of Compounds

AL1

FDA Fetal dysmorphogenesis, Rodents, full set

2023

AL2

FDA Fetal dysmorphogenesis, Rodents part A

1313

AL3

FDA Fetal dysmorphogenesis, Rodents part B

1312

AL4

FDA Fetal dysmorphogenesis, Rat, full set

1764

AL5

FDA Fetal dysmorphogenesis, Rat, part A

1119

AL6

FDA Fetal dysmorphogenesis, Rat, part B

1118

AL7

FDA Fetal dysmorphogenesis, Mouse, full set

976

AL8

FDA Fetal dysmorphogenesis, Mouse, part A

644*

AL9

FDA Fetal dysmorphogenesis, Mouse, part B

643*

AX1

FDA developmental toxicity dysmorphogenesis rabbit, control

1016*

AX2

FDA developmental toxicity dysmorphogenesis rabbit, part A

361*

AX3

FDA developmental toxicity dysmorphogenesis rabbit, part B

361*

AX4

FDA developmental toxicity dysmorphogenesis rabbit, part C

360*

AX5

FDA developmental toxicity dysmorphogenesis rabbit, part D

360*

AM1

FDA developmental toxicity visceral dysmorphogenesis rodent composite, control

2022*

AM2

FDA developmental toxicity visceral dysmorphogenesis rodent composite, part A

893*

AM3

FDA developmental toxicity visceral dysmorphogenesis rodent composite, part B

893*

AM4

FDA developmental toxicity visceral dysmorphogenesis rodent composite, part C

892*

AM5

FDA developmental toxicity visceral dysmorphogenesis rat, control

1762*

AM6

FDA developmental toxicity visceral dysmorphogenesis rat, part A

619*

AM7

FDA developmental toxicity visceral dysmorphogenesis rat, part B

619*

AM8

FDA developmental toxicity visceral dysmorphogenesis rat, part C

619*

AM9

FDA developmental toxicity visceral dysmorphogenesis rat, part D

619*

AT1

FDA developmental toxicity visceral dysmorphogenesis mouse, control

977*

AT2

FDA developmental toxicity visceral dysmorphogenesis mouse, part A

323*

AT3

FDA developmental toxicity visceral dysmorphogenesis mouse, part B

322*

AT4

FDA developmental toxicity visceral dysmorphogenesis mouse, part C

322*

AT5

FDA developmental toxicity visceral dysmorphogenesis mouse, part D

322*

AT6

FDA developmental toxicity visceral dysmorphogenesis rabbit, control

1016*

* indicates modules updated or acquired in 2008.

 

Reproductive toxicity in male rodents

 Module ID  Description # of Compounds

AO1

FDA Reproductive toxicity in adult males, Rodents, full set

791

AO2

FDA Reproductive toxicity in adult males, Rodents part A

608

AO3

FDA Reproductive toxicity in adult males, Rodents part B

607

AO4

FDA Reproductive toxicity in adult males, Rat, full set

721

AO5

FDA Reproductive toxicity in adult males, Rat, part A

553

AO6

FDA Reproductive toxicity in adult males, Rat, part B

553

AO7

FDA Reproductive toxicity in adult males, Mouse, full set

146

AP1

FDA Sperm toxicity, Mammal, full set

917

AP2

FDA Sperm toxicity, Mammal, part A

575

AP3

FDA Sperm toxicity, Mammal, part B

574

AP4

FDA Sperm toxicity, Rat, full set

730

AP5

FDA Sperm toxicity, Rat, part A

452

AP6

FDA Sperm toxicity, Rat, part B

452

AP7

FDA Sperm toxicity, Mouse, full set

262

 

Reproductive toxicity in female rodents

 Module ID  Description # of Compounds

AN1

FDA Reproductive toxicity in females, Rodents, full set

968

AN2

FDA Reproductive toxicity in females, Rodents part A

424

AN3

FDA Reproductive toxicity in females, Rodents part B

424

AN4

FDA Reproductive toxicity in females, Rodents part C

391

AN5

FDA Reproductive toxicity in females, Rat, full set

902

AN6

FDA Reproductive toxicity in females, Rat, part A

455

AN7

FDA Reproductive toxicity in females, Rat, part B

455

AN8

FDA Reproductive toxicity in females, Rat, part C

454

AN9

FDA Reproductive toxicity in females, Mouse, full set

151

 

Neurotoxicity

 Module ID  Description # of Compounds

AQ1

FDA Behavioral toxicity, Rodents, full set

670

AQ2

FDA Behavioral toxicity, Rodents part A

416

AQ3

FDA Behavioral toxicity, Rodents part B

416

AQ4

FDA Behavioral toxicity, Rodents part C

416

AQ5

FDA Behavioral toxicity, Rat, full set

627

AQ6

FDA Behavioral toxicity, Rat, part A

384

AQ7

FDA Behavioral toxicity, Rat, part B

384

AQ8

FDA Behavioral toxicity, Rat, part C

383

AQ9

FDA Behavioral toxicity, Mouse, full set

172

 

Fetal development

 Module ID  Description # of Compounds

AH1

FDA fetal development fetal growth retardation rodent composite, control

2022*

AH2

FDA fetal development fetal growth retardation rodent composite, part A

1305*

AH3

FDA fetal development fetal growth retardation rodent composite, part B

1304*

AH4

FDA fetal development fetal growth retardation rat, control

1762*

AH5

FDA fetal development fetal growth retardation rat A

1097*

AH6

FDA fetal development fetal growth retardation rat B

1098*

AH7

FDA fetal development fetal growth retardation mouse, control

977*

AH8

FDA fetal development fetal growth retardation mouse A

601*

AH9

FDA fetal development fetal growth retardation mouse B

600*

AX1

FDA fetal development fetal growth retardation rabbit, control

1015*

AX2

FDA fetal development fetal growth retardation rabbit A

319*

AX3

FDA fetal development fetal growth retardation rabbit B

318*

AX4

FDA fetal development fetal growth retardation rabbit C

318*

AX5

FDA fetal development fetal growth retardation rabbit D

318*

AI1

FDA fetal development fetal weight decrease rodent composite, control

2022*

AI2

FDA fetal development fetal weight decrease rodent composite A

1561*

AI3

FDA fetal development fetal weight decrease rodent composite B

1561*

AI4

FDA fetal development fetal weight decrease rat, control

1762*

AI5

FDA fetal development fetal weight decrease rat, A

1111*