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Teratogenicity

Developmental toxicity
| Module ID |
Description |
# of Compounds |
|
A41 |
Retinoids 39 compounds data from C.Willhite |
39 |
|
A42 |
Retinoids 37 compounds data from Kochhar |
37 |
|
A43 |
Developmental Toxicity Triazoles antifungal triazole alcohols |
66 |
|
A44 |
Developmental Toxicity Composite |
275 |
|
A45 |
Developmental Toxicants in Mouse |
101 |
|
A46 |
Developmental Toxicants in Rat |
134 |
|
A47 |
Developmental Toxicants in Rabbit |
66 |
|
A48 |
Developmental Toxicants in Human |
119 |
|
A49 |
FDA TERIS Developmental Toxicity in Humans |
323 |
|
A4A |
Risk of Developmental Toxicity |
323 |
|
A4B |
Developmental Toxicants in Hamster |
192 |
Dysmorphogenesis
| Module ID |
Description |
# of Compounds |
|
AL1 |
FDA Fetal dysmorphogenesis, Rodents, full set |
2023 |
|
AL2 |
FDA Fetal
dysmorphogenesis, Rodents part A |
1313 |
|
AL3 |
FDA Fetal dysmorphogenesis, Rodents part B |
1312 |
|
AL4 |
FDA Fetal dysmorphogenesis, Rat, full set |
1764 |
|
AL5 |
FDA Fetal dysmorphogenesis, Rat, part A |
1119 |
|
AL6 |
FDA Fetal dysmorphogenesis, Rat, part B |
1118 |
|
AL7 |
FDA Fetal dysmorphogenesis, Mouse, full set |
976 |
|
AL8 |
FDA Fetal dysmorphogenesis, Mouse, part A |
644* |
|
AL9 |
FDA Fetal
dysmorphogenesis, Mouse, part B |
643* |
|
AX1 |
FDA developmental
toxicity dysmorphogenesis rabbit, control |
1016* |
|
AX2 |
FDA developmental
toxicity dysmorphogenesis rabbit, part A |
361* |
|
AX3 |
FDA developmental
toxicity dysmorphogenesis rabbit, part B |
361* |
|
AX4 |
FDA developmental
toxicity dysmorphogenesis rabbit, part C |
360* |
|
AX5 |
FDA developmental
toxicity dysmorphogenesis rabbit, part D |
360* |
|
AM1 |
FDA developmental
toxicity visceral dysmorphogenesis rodent composite, control |
2022* |
|
AM2 |
FDA developmental
toxicity visceral dysmorphogenesis rodent composite, part A |
893* |
|
AM3 |
FDA developmental
toxicity visceral dysmorphogenesis rodent composite, part B |
893* |
|
AM4 |
FDA developmental
toxicity visceral dysmorphogenesis rodent composite, part C |
892* |
|
AM5 |
FDA developmental
toxicity visceral dysmorphogenesis rat, control |
1762* |
|
AM6 |
FDA developmental
toxicity visceral dysmorphogenesis rat, part A |
619* |
|
AM7 |
FDA developmental
toxicity visceral dysmorphogenesis rat, part B |
619* |
|
AM8 |
FDA developmental
toxicity visceral dysmorphogenesis rat, part C |
619* |
|
AM9 |
FDA developmental
toxicity visceral dysmorphogenesis rat, part D |
619* |
|
AT1 |
FDA developmental
toxicity visceral dysmorphogenesis mouse, control |
977* |
|
AT2 |
FDA developmental
toxicity visceral dysmorphogenesis mouse, part A |
323* |
|
AT3 |
FDA developmental
toxicity visceral dysmorphogenesis mouse, part B |
322* |
|
AT4 |
FDA developmental
toxicity visceral dysmorphogenesis mouse, part C |
322* |
|
AT5 |
FDA developmental
toxicity visceral dysmorphogenesis mouse, part D |
322* |
|
AT6 |
FDA developmental
toxicity visceral dysmorphogenesis rabbit, control |
1016* |
* indicates modules updated or
acquired in 2008.
Reproductive toxicity in male rodents
| Module ID |
Description |
# of Compounds |
|
AO1 |
FDA Reproductive
toxicity in adult males, Rodents, full set |
791 |
|
AO2 |
FDA Reproductive
toxicity in adult males, Rodents part A |
608 |
|
AO3 |
FDA Reproductive
toxicity in adult males, Rodents part B |
607 |
|
AO4 |
FDA Reproductive
toxicity in adult males, Rat, full set |
721 |
|
AO5 |
FDA Reproductive
toxicity in adult males, Rat, part A |
553 |
|
AO6 |
FDA Reproductive
toxicity in adult males, Rat, part B |
553 |
|
AO7 |
FDA Reproductive
toxicity in adult males, Mouse, full set |
146 |
|
AP1 |
FDA Sperm
toxicity, Mammal, full set |
917 |
|
AP2 |
FDA Sperm
toxicity, Mammal, part A |
575 |
|
AP3 |
FDA Sperm
toxicity, Mammal, part B |
574 |
|
AP4 |
FDA Sperm
toxicity, Rat, full set |
730 |
|
AP5 |
FDA Sperm
toxicity, Rat, part A |
452 |
|
AP6 |
FDA Sperm
toxicity, Rat, part B |
452 |
|
AP7 |
FDA Sperm
toxicity, Mouse, full set |
262 |
Reproductive toxicity in female rodents
| Module ID |
Description |
# of Compounds |
|
AN1 |
FDA Reproductive
toxicity in females, Rodents, full set |
968 |
|
AN2 |
FDA Reproductive
toxicity in females, Rodents part A |
424 |
|
AN3 |
FDA Reproductive
toxicity in females, Rodents part B |
424 |
|
AN4 |
FDA Reproductive
toxicity in females, Rodents part C |
391 |
|
AN5 |
FDA Reproductive
toxicity in females, Rat, full set |
902 |
|
AN6 |
FDA Reproductive
toxicity in females, Rat, part A |
455 |
|
AN7 |
FDA Reproductive
toxicity in females, Rat, part B |
455 |
|
AN8 |
FDA Reproductive
toxicity in females, Rat, part C |
454 |
|
AN9 |
FDA Reproductive
toxicity in females, Mouse, full set |
151 |
Neurotoxicity
| Module ID |
Description |
# of Compounds |
|
AQ1 |
FDA Behavioral
toxicity, Rodents, full set |
670 |
|
AQ2 |
FDA Behavioral
toxicity, Rodents part A |
416 |
|
AQ3 |
FDA Behavioral
toxicity, Rodents part B |
416 |
|
AQ4 |
FDA Behavioral
toxicity, Rodents part C |
416 |
|
AQ5 |
FDA Behavioral
toxicity, Rat, full set |
627 |
|
AQ6 |
FDA Behavioral
toxicity, Rat, part A |
384 |
|
AQ7 |
FDA Behavioral
toxicity, Rat, part B |
384 |
|
AQ8 |
FDA Behavioral
toxicity, Rat, part C |
383 |
|
AQ9 |
FDA Behavioral
toxicity, Mouse, full set |
172 |
Fetal development
| Module ID |
Description |
# of Compounds |
|
AH1 |
FDA fetal development fetal growth retardation rodent
composite, control |
2022* |
|
AH2 |
FDA fetal development fetal growth retardation rodent
composite, part A |
1305* |
|
AH3 |
FDA fetal development fetal growth retardation rodent
composite, part B |
1304* |
|
AH4 |
FDA fetal development fetal growth retardation rat, control |
1762* |
|
AH5 |
FDA fetal development fetal growth retardation rat A |
1097* |
|
AH6 |
FDA fetal development fetal growth retardation rat B |
1098* |
|
AH7 |
FDA fetal development fetal growth retardation mouse, control |
977* |
|
AH8 |
FDA fetal development fetal growth retardation mouse A |
601* |
|
AH9 |
FDA fetal development fetal growth retardation mouse B |
600* |
|
AX1 |
FDA fetal development fetal growth retardation rabbit,
control |
1015* |
|
AX2 |
FDA fetal development fetal growth retardation rabbit A |
319* |
|
AX3 |
FDA fetal development fetal growth retardation rabbit B |
318* |
|
AX4 |
FDA fetal development fetal growth retardation rabbit C |
318* |
|
AX5 |
FDA fetal development fetal growth retardation rabbit D |
318* |
|
AI1 |
FDA fetal development fetal weight decrease rodent composite,
control |
2022* |
|
AI2 |
FDA fetal development fetal weight decrease rodent composite
A |
1561* |
|
AI3 |
FDA fetal development fetal weight decrease rodent composite
B |
1561* |
|
AI4 |
FDA fetal development fetal weight decrease rat, control |
1762* |
|
AI5 |
FDA fetal development fetal weight decrease rat, A |
1111* |
|
AI6 |
FDA fetal development fetal weight decrease rat, B |
1110* |
|
AI7 |
FDA fetal development fetal weight decrease mouse, control |
977* |
|
AI8 |
FDA fetal development fetal weight decrease mouse, A |
609* |
|
AI9 |
FDA fetal development fetal weight decrease mouse, B |
610* |
|
AW1 |
FDA fetal development fetal weight decrease rabbit, control |
1015* |
|
AW2 |
FDA fetal development fetal weight decrease rabbit, A |
349* |
|
AW3 |
FDA fetal development fetal weight decrease rabbit, B |
348* |
|
AW4 |
FDA fetal development fetal weight decrease rabbit, C |
348* |
|
AW5 |
FDA fetal development fetal weight decrease rabbit, D |
348* |
* indicates modules updated or
acquired in 2008.
Fetal survival
| Module ID |
Description |
# of Compounds |
|
AR1 |
FDA fetal survival fetal death rodent composite, control |
2022* |
|
AR2 |
FDA fetal survival fetal death rodent composite A |
1831* |
|
AR3 |
FDA fetal survival fetal death rodent composite B |
1830* |
|
AR4 |
FDA fetal survival fetal death rat, control |
1762* |
|
AR5 |
FDA fetal survival fetal death rat A |
977* |
|
AR6 |
FDA fetal survival fetal death rat B |
1015* |
|
AR7 |
FDA fetal survival fetal death mouse, control |
636* |
|
AR8 |
FDA fetal survival fetal death mouse A |
635* |
|
AR9 |
FDA fetal survival fetal death mouse B |
786* |
|
AS1 |
FDA fetal survival fetal death rabbit, control |
1017* |
|
AS2 |
FDA fetal survival fetal death rabbit A |
1017* |
|
AS3 |
FDA fetal survival fetal death rabbit B |
1017* |
|
AG1 |
FDA fetal survival post-implantation rodent composite,
Control |
2022* |
|
AG2 |
FDA fetal survival post-implantation rodent composite A |
1566* |
|
AG3 |
FDA fetal survival post-implantation rodent composite B |
1566* |
|
AG4 |
FDA fetal survival post-implantation rat, control |
1762* |
|
AG5 |
FDA fetal survival post-implantation rat A |
1104* |
|
AG6 |
FDA fetal survival post-implantation rat B |
1104* |
|
AG7 |
FDA fetal survival post-implantation mouse, control |
977* |
|
AG8 |
FDA fetal survival post-implantation mouse A |
633* |
|
AG9 |
FDA fetal survival post-implantation mouse B |
748* |
|
AV1 |
FDA fetal survival post-implantation rabbit, control |
1015* |
|
AV2 |
FDA fetal survival post-implantation rabbit A |
362* |
|
AV3 |
FDA fetal survival post-implantation rabbit B |
362* |
|
AV4 |
FDA fetal survival post-implantation rabbit C |
362* |
|
AV5 |
FDA fetal survival post-implantation rabbit D |
361* |
|
AJ1 |
FDA fetal survival pre-implantation rodent composite control |
2022* |
|
AJ2 |
FDA fetal survival pre-implantation rodent composite A |
1269* |
|
AJ3 |
FDA fetal survival pre-implantation rodent composite B |
1268* |
|
AJ4 |
FDA fetal survival pre-implantation rodent composite C |
1762* |
|
AJ5 |
FDA fetal survival pre-implantation rat, control |
829* |
|
AJ6 |
FDA fetal survival pre-implantation rat A |
829* |
|
AJ7 |
FDA fetal survival pre-implantation rat B |
828* |
|
AJ8 |
FDA fetal survival pre-implantation rat C |
977* |
|
AJ9 |
FDA fetal survival pre-implantation mouse, control |
460* |
|
AU1 |
FDA fetal survival pre-implantation mouse A |
460* |
|
AU2 |
FDA fetal survival pre-implantation mouse B |
459* |
|
AU3 |
FDA fetal survival pre-implantation mouse C |
1015* |
|
AU4 |
FDA fetal survival pre-implantation rabbit, control |
325* |
|
AU5 |
FDA fetal survival pre-implantation rabbit A |
325* |
|
AU6 |
FDA fetal survival pre-implantation rabbit B |
325* |
|
AU7 |
FDA fetal survival pre-implantation rabbit C |
325* |
* indicates modules updated or
acquired in 2008.
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